Search
Now showing items 21-28 of 28
Retrospective descriptive evaluation of empiric carbapenem-sparing regimens versus carbapenem use in non-intensive care patients at a district hospital in South Africa
(University of Western Cape, 2021)
Antimicrobial resistance is a global concern associated with increased morbidity and mortality. It has been estimated that, by 2050, the continuous escalation of antimicrobial resistance, globally, will result in more ...
Structure-Based Virtual Screening of Selected Malaria Box Compounds Against a Multi-Staged Protein (Falstatin) in Plasmodium falciparum
(University of the Western Cape, 2021)
Malaria disease poses substantial health risks to many nations, especially in Africa, where it primarily affects pregnant women, children, and immunocompromised patients. However, current antimalarial drugs have limitations ...
Current practices of urinary tract infection management: An observational study at primary healthcare level
(University of Western Cape, 2021)
Antibiotic resistance (ABR) is a global healthcare burden complicating the treatment of various infections. The infectious diseases burden is heavy in primary care. Urinary tract infections (UTIs) are common outpatient ...
Antiasthmatic properties of Lippia javanica and Myrothamnus flabellifolius using an in vitro model
(University of the Western Cape, 2022)
Asthma is a reversible, chronic inflammatory disease
that causes obstruction to the airways that causes an increase in airway hyperresponsiveness
that leads to recurrent episodes of chest tightness and coughing.
Lippia ...
Design of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinoma
(University of the Western Cape, 2023)
Introduction: Oral squamous cell carcinoma is the most common and aggressive cancer occurring in the oral cavity. Intravenous chemotherapy remains a pivotal part of treatment for the disease; however, these drugs cause ...
Exploring a participatory multi-stakeholder engagement approach to address chronic medicine use
(University of the Western Cape, 2023)
Background: In South Africa, chronic diseases (CD) fall into the quadruple burdens of diseases. In 2018 the World Health Organization (WHO) reported that chronic diseases were responsible for more than fifty percent of ...
Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
(University of the Western Cape, 2023)
One of the crucial ways by which Staphylococcus aureus develops resistance to antibiotics is biofilm formation, a protective mechanism involving extracellular polymeric substance (EPS) matrix that shields microorganisms ...
The transition of regulatory services from drug regulatory unit to Botswana medicines regulatory authority: an evaluation of the changes in regulatory services from the industry’s perspective
(University of the Western Cape, 2023)
The Drug Regulatory Unit (DRU) was established by the Ministry of Health (MoH) to enforce the Drugs and Related Substances Act of 1992 in line with the Botswana National Drug Policy (BNDP) adopted in 2002 and the National ...